Burns treatment with Ganikderma® products

Burn is an injury caused by excessive heat: skin is affected first, causing tissue damage and blood clotting in the affected area.

The etiology of burns

Thermal burns

Flame burn wound Usually has many causes
Can be favored by volatile liquids and oil
Can be of any depth, usually presents as a combination of burns of different depths
Burns caused by hot liquid About 60% of burns in children are caused by hot liquid
The most important cause is the hot water or hot drinks
Contact burns Often present in children on hands, face or feet
Can be caused by heat sources (stove lid, etc.).

Electrical burns

Flame burn wound Because of domestic sources <240V
Usually, small area burns, localized on extremities
High voltage Due wire voltage (1.000V ˃), industrial accidents
It can lead to serious systemic injuries

Chemical burns

Acids Are Painful
Usually, small area burns, localized on extremities
pH testing is required
Abundant washing of the wound with or without specific antidote is essential
Alkaline substances It can appear without pain
The causes can include cleaning agents, bleaching
pH testing is required
Often result in deep wounds
It is essential to wash abundant (more than 24 hours) wound with or without specific antidote
Organic matter Pitch
Treatment requires water cooling and removal of pitch (can be used sunflower oil)
Chemical cleaning with kerosene, gasoline, acetone or alcohol may cause local irritation, or may be toxic, so that these substances are not recommended

Classification of burns

Burn Surface Area Estimation

Extent of burns is appreciated by a percentage scale indicating the affected area of the body. Burn severity is assessed considering the depth and surface area affected, and the patient’s health and age.

To estimate body surface affected, were used together, the method “rule of nine” and method “Lund-Bowder” – the most effective method is “Rule of Nine” which allows rapid estimation of adult patients (see Fig. 2 .).This method takes into account the patient’s age. Lund-Bowder method (1944) is used for a more accurate assessment of burns by comparing the affected area as a percentage of total body surface (Fig. 1).

The skin is the body organ that usually suffer the greatest injury from burns.

Lund – Bowder Method

Surfaces of the body are rated according to the table below:

Age < 1 year 1 year 5 years 10 years 15 years Adult
A = front or back of the head 9,5% 8,5% 6,5% 5,5% 4,5% 3,5%
B = front or back of thigh 2,75% 3,25% 4% 4,25% 4,5% 4,75%
C = foot (front or back) 2,5% 2,5% 2,75% 3% 3,25% 3,5%

Superficial burns I degree

In this case, only the top layer of the epithelium is affected, the main features of superficial burns are: skin is intact but shows signs of redness and is very sensitive at touching. On the skin minimal tissue injuries are visible, but the apparition of blisters is possible in a 48 hours timeframe from the initial moment of the injury.

Superficial burns II degree

It extends beyond the epidermis, the dermis and presents the following characteristics:

  • it is associated with the formation of blisters, redness and exudate;
  • is very painful;

Burns III degree

Lie in the deeper layers of the dermis and can affect the hair follicle or sweat gland. Has the following characteristics: the wound is white-yellowish, with large blisters, not very painful, presenting insensitive areas.

Burns IV degree

Both epidermis and dermis are destroyed. Damage can stretch the subcutaneous layer and can be unhealthy muscle and bone. It is characterized by:

  1. May look waxy white, blood-red or gray, the pain is minimal or absent in the wound
  2. It is necessary to apply a skin graft to promote healing, scar formation is influenced by graft technique.

It is often difficult to assess the exact depth of the burn, many of which have varying depths. All patients should be reviewed in 48 to 72 hours after burn and watch until complete wound epithelization.


Burn healing

Superficial burns – heal by epithelialization from epidermal cells. 2nd degree burns – heal by granulation, contraction and epithelialization. Burns of III and IV degree – destroying the annexes and can not heal by epithelization. Contraction reduces surface burn and eventually wound edges are touching each other. Like any wound, heal burns passing through the following stages:

Haemostasis

Physiological response is immediately following an injury. Haemostasis is conducted by combining vasoconstriction to prevent blood loss with coagulants release factors that are as antibacterial barrier and as a framework for cell migration (Benbow 2005).

Inflammatory phase

Is normal cellular and vascular response at any damage (injury); healing can not progress if the inflammation does not occur (Timmons 2006). The duration of this phase is often higher in chronic wounds.

Granulation phase (proliferative)

Once wound contraction occurred, new epithelial tissue may develop at the wound surface. New skin cells begin to migrate from the wound edges, also form around of follicle of the hair, sebaceous glands and sweat glands (Timmons 2006). New epithelial cells are white / pink and migration stops once they meet other epithelial cells in the wound, a phenomenon known as contact inhibition. Epithelial migration is accelerated in moist environments, which makes epithelial cells to migrate more easily (Winter 1962).

Epithelization phase (maturation)

This phase refers to the phase of remodeling and sometimes can take up to 18 months (Silver 1994). In the case of chronic wounds, this phase may last for a longer duration. During epithelization, the wound starts to heal and the scar changes significantly the color (Timmons 2006).

Moist wound healing

Since the 1980s, it was accepted that environment “wet” is optimal for wound healing. The concept was introduced by George Winter who, in 1962, conducted animal studies comparing the crust of wound treatet in „dry”  environment,with the crust of wound treated in moist environment (covered with semi-permeable film). Results showed that epithelization was two times faster when wound covered with semi-permeable film. By 1980, Winter conducting other clinical studies which have confirmed that moist wound therapy has other benefits, such as reducing pain. Other studies have shown that autolytic debridement, is favored by moist environment (eg Freidman 1983).


Burns treatment

First aid in burn cases

The first reflex when a burn occurs is to cool the wound with cold water. As cooling is done quickly, the more efficient, the local heat cooling diminishes, leading to pain relief and avoid extending inflammation and edema. Traditional in burns is to cool with water after rule of three [15], ie;

  • Water at 150
  • From a distance of 15 cm from the burning
  • For about 15 minutes

Dressings used in the treatment of burns

Dressings purpose is to absorb exudate from the wound and prevent its colonization by pathogenic bacteria.

  • Superficial burns – can be painful, requiring analgesics.
  • II degree burns – require cleaning with saline or water to remove debris sites. Traditionally, these burns are treated with dressings impregnated with ointment.
  • Burns III and IV degree – are generally required excision of necrotic tissue and apply skin grafts for speeding healing.

Burn management should:

  • Ensure debridement, if necessary
  • Favor rapid healing
  • To prevent / detect infection

GANIKDERMA® products in burn treatment

According to Clinical Investigation (EN ISO 14155): Burns surface decreased by 50% after 5,12 days of treatment with GANIKDERMA® products, their evolution towards healing, was made  without notice side effects.

Burn healing time ranged between 3 and 26 days depending on the independent variables of treatment such as lesion agent (flame, hot liquid, etc.), subject age, and associated medical affections. The average time complete healing of burns, was 14,48 days, wounds was covered with newly formed epithelium tissue with high quality.

Depending on burn degree, healing occurred as follows:

  • Burns IIa degree, were healed in a range between 3 and 11 days, with an average of 7,56 days.
  • Burns IIb degree, were healed in a range between 10 and 22 days, with an average of 13,07 days.
  • Burns III degree, were healed in a range between 20 and 26 days, with an average of 22,83 days.

In terms of burn volume, after 4,5 days of treatment, it was reduced by 50% and after 10 days of treatment, the average volume of burns represents 10% of the original. During treatment with GANIKDERMA® products, no burn was infected and had no smell.

The average intensity of pain felt experienced by subjects at dressing made with GANIKDERMA® products removal from burn surface, estimated according Wong-Baker scale, was 1,05, which is a pain than can be overlooked.

Dressings made with GANIKDERMA® products (Impregnated Compresses or/and Ointment), was changed on average every 2,07 days; ease of application and ease of dressing removal being assessed by doctors as a very good. It should be noted that dressing made GANIKDERMA® products change was atraumatic, without trauma to newly tissues (granulation and epithelization).

Burns healing during treatment with GANIKDERMA® products ended with a very good quality of epithelium, with very good results in terms of aesthetics, without developing hypertrophic scars – particularly important in case of patients with burns located on facial or chest area, especially in case of female patients. This has a very positive impact on quality of life of patients who had burns, they managed to reintegrate into society.

The above data prove great efficiency of GANIKDERMA® products in treatment of burns in terms of shortening the time of healing, a high quality of epithelization, Which has an important meaning in case of patients with burns localized on face or chest.

GANIKDERMA® products provide a favorable microclimate for wound healing by stimulating epithelial cells, keratinocytes and endothelial cells, promotes the vascularization of newly tissues and normal healing mechanisms (wet cell proliferation), also preventing necrosis.

Effective management during treatment results in the removal of excess secretions, which combined with ointment absorbs and maintains an optimal fluid balance.

No special precautions are necessary regarding use of GANIKDERMA® products, unless the patient is allergic to a component of ointment.


Clinical cases cured with GANIKDERMA®

Patient 1 Burns

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Patient 2 Burns

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Patient 3 Burns

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Patient 4 Burns

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Patient 5 Burns

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Patient 6 Burns

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Patient 7 Burns

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Patient 8 Burns

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